Trends and correlation between antibacterial consumption and carbapenem resistance in gram-negative bacteria in a tertiary hospital in China from 2012 to 2019

Abstract Background To investigate the trends and correlation between antibacterial consumption carbapenem resistance in Gram-negative bacteria from 2012 to 2019 a tertiary-care teaching hospital southern China. Methods This retrospective study included data hospital-wide inpatients collected January December 2019. Data on were expressed as defined daily doses (DDDs)/1000 patient-days. Antibacterials classified according Anatomical Therapeutic Chemical (ATC) classification system. The antimicrobial usage analyzed by linear regression, while Pearson analysis was used for assessing correlations. Results An increasing trend annual of tetracyclines, ?-lactam/?-lactamase inhibitor (BL/BLI) combinations, carbapenems observed ( P < 0.05). Carbapenem Acinetobacter baumannii A. ) significantly increased 0.05) 18% 60% Moreover, significant positive correlations found Escherichia coli E. ; carbapenems, rate positively correlated with cephalosporin/?-lactamase (C/BLI) combinations 0.01) tetracyclines We also that use quinolones Burkholderia cepacia B. 0.05), uses penicillin/?-Lactamase (P/BLI) reduced Enterobacter cloacae carbapenems. Conclusion These results revealed antibiotics rates bacteria. Implementing proper management strategies reducing unreasonable drugs may be an effective measure reduce spread carbapenem-resistant (CRGN), which should confirmed further studies.